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We believe that this switch is only activated under conditions that are found at certain sites on the X chromosome. This would ensure that dosage compensation is restricted to genes on the X, says Becker. The researchers now assume that long RNAs play a much more active role in other regulatory complexes than has been suspected hitherto. Up to now, these RNAs have been seen as passive scaffolds for the binding of proteins.
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We think though that they modulate the activity of the proteins they associate with. And we have now shown this for the DCC, Becker says. A study of mortality and fertility patterns among seven species of wild apes and monkeys and their relatives, compared with similar data from hunter-gatherer humans, shows that menopause sets humans apart from other primates. Nonhuman primates aren't immune to the fading female fertility that comes with age, the researchers say.
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