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However, among women coffee drinkers only, this fell to 14%. The researchers said their findings could hardly by explained by bias or uncontrolled confounding. Cancer Studies have also suggested coffee consumption is linked to a lower risk for some cancers, including endometrial, aggressive prostate, estrogen-negative breast cancer, liver cancer, and a common form of skin cancer, but not others (eg esophageal). In 2011, researchers working with data from the Nurses' Health Study published findings that showed coffee drinkers who consumed more than four cups a day had a 25% lower risk of developing endometrial cancer. Senior researcher Edward Giovannucci, professor of nutrition and epidemiology at the Harvard School of Public Health, said coffee is starting to emerge as a protective agent in cancers that are linked to obesity, estrogen and insulin. He and his colleagues suggest antioxidant and anti-inflammatory substances in coffee may be responsible for anti-cancer activity. Giovannucci said lab tests show coffee has more antioxidants than most fruits and vegetables. Giovannucci was also co-author of another 2011 study that found men who regularly drink coffee appear to have a lower risk of developing an aggressive, lethal form of prostate cancer. They also found the lower risk was the same for caffeinated as for decaffeinated coffee.
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A link with coffee consumption and lower risk of estrogen-negative breast cancer was made in a Swedish study that also appeared in 2011. When they first looked at their data, the researchers from Karolinska Institute found women who drank coffee had a lower incidence of breast cancer than women who rarely drank coffee, but when they took into account other risk factors, including lifestyle and age, they found the lower risk was only measurable for estrogen-negative breast cancer. The case for linking reduced risk of liver cancer to coffee drinking has been building steadily for a while. In 2007, a study led by the Mario Negri Institute for Pharmacological Research in Milan, Italy, that did a pooled analysis of ten studies that included over 2,200 people with hepatocellular carcinoma (HCC), reported that among coffee drinkers overall, there was a 41 per cent reduction in risk of HCC compared to those who never drank coffee.
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